Animal Information Diazepam has long been demonstrated to provide increased incidences of fetal malformations in mice and hamsters when given orally at solitary doses of 100 mg/kg or higher (approximately twenty times the utmost encouraged adult dose [0.four mg/kg/day] or increased on the mg/m 2 foundation). Cleft palate and exencephaly are the co
Omtrent seven-nine % af den kaukasiske befolkning har variationer i CYP2D6 genet som koder for ingen- eller nedsat aktivitet af CYP2D6 (se personlig medicin ). Tramadol et produg der omdannes til den aktive metabolit via CYP2D6. Patienter med nedsat eller manglende aktivitet af CYP2D6, vil have reduceret- eller manglende effekt af tramadol.Eksperte
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